Chemical Overview: 1,25 Di-Hydroxy Vitamin D, also known as calcitriol, is the biologically active form of vitamin D. It is produced in the kidneys from 25-hydroxy vitamin D (calcidiol) and is crucial for various physiological processes in the body.
Role in Health: Calcitriol plays a vital role in regulating calcium and phosphate levels, which are essential for maintaining healthy bones and teeth. It also influences immune function, cell growth, and differentiation, contributing to overall health.
Activation Process: The conversion of vitamin D into its active form involves two steps: first in the liver, where vitamin D is converted to 25-hydroxy vitamin D, and then in the kidneys, where it is converted to 1,25 di-hydroxy vitamin D. This process is tightly regulated by the body based on its needs.
Testing and Clinical Significance: Measuring levels of 1,25 di-hydroxy vitamin D can help diagnose certain health conditions, such as chronic kidney disease or hyperparathyroidism, where calcium regulation is disrupted. It is also important in evaluating calcium absorption in the body.
Deficiency and Disorders: Although 1,25 di-hydroxy vitamin D is crucial for health, its levels are typically maintained within a narrow range. Disorders related to vitamin D metabolism, such as rickets in children or osteomalacia in adults, may occur if there is an imbalance in the synthesis or action of this active form.
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